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sting inhibitor h 151  (InvivoGen)


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    Structured Review

    InvivoGen sting inhibitor h 151
    Sting Inhibitor H 151, supplied by InvivoGen, used in various techniques. Bioz Stars score: 97/100, based on 149 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/sting+inhibitor+h+151/H-151/pm42140967-273-31-35
    Average 97 stars, based on 149 article reviews
    sting inhibitor h 151 - by Bioz Stars, 2026-10
    97/100 stars

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    Related Articles

    Blocking Assay:

    Article Title: ADA2-deficient cells exhibit increased levels of cell death and metabolic disturbances
    Article Snippet: TNF inhibition was achieved by incubation with 5 μg/mL adalimumab (#A2010, Selleck Chemicals GmbH). .. Ruxolitinib (5 μM, #S1378, Selleck Chemicals GmbH) was used to block JAK1/2 signalling and the STING-inhibitor H-151 (1 μM, #inh-h151, InvivoGen) served to examine DNA sensing. ..

    other:

    Article Title: ADA2-deficient cells exhibit increased levels of cell death and metabolic disturbances.
    Article Snippet: Necroptosis was induced by 30-minute incubation with 100 nM birinapant (#S7015; Selleck Chemicals GmbH) and 20 μM Z-VAD-FMK (#S7023; Selleck Chemicals GmbH) followed by 4-hour incubation with 20 ng/mL TNF-α (#rcyc-htnfa; InvivoGen).

    Article Title: Pseudorabies virus infection triggers pUL46-mediated phosphorylation of connexin-43 and closure of gap junctions to promote intercellular virus spread
    Article Snippet: The autophagy inhibitor chloroquine diphosphate (catalog number 4109) was purchased from Tocris Bioscience (Bristol, United Kingdom).

    Concentration Assay:

    Article Title: α-Synuclein aggregates induce mitochondrial damage and trigger innate immunity to drive neuron–microglia communication
    Article Snippet: .. For inflammatory modulations, following reagents were used with associated treatment concentration and durations: STING activator – diABZI (SelleckChem – compound 3, S8796; 2.5 μM for 2h towards the end of experiment), STING inhibitor – H-151 (Invivogen InvitroFit TM , inh-h151; 0.5 μg/mL for 16h for TNT assessment experiments, and 24h for α-Syn transfer experiments), NF-κB inhibitor – JSH-23 (Sigma, J4455; 10 μM for 16h for TNT assessment experiments, and 24h for α-Syn transfer experiments), human cGAS inhibitor – G140 (Invivogen InvitroFit TM , inh-g140; 10 μM for 16h), Bcl-2 inhibitor – ABT-737 (Sigma, 197333; 10 μM for 6h, 12h, or 24h) co-treated with pan-caspase inhibitor – Q-VD-OPh (Non-O- methylated, Sigma, 551476, 10 μM), human IL-1α (Sigma, I2778; 3 ng/mL for 24h), human IL-1β (Sigma, H6291; 20 ng/mL for 24h), human TNF-α (Merck Millipore, 654205; 50 ng/mL for 24h), TLR4 inhibitor – TAK-242 (Tocris, 6587; 10 μM for 16h), TLR2 inhibitor – TL2-C29 (Invivogen InvitroFit TM , inh-C29; 100 μM for 16h), lysosomotropic agent LLOMe (Sigma, L7393; 1 mM for 1h towards the end of experiment), mitochondrial electron transport chain uncoupler CCCP (Sigma, C2759; 20 μM for 2h). .. The following dyes were used: MitoTracker Red CMX Ros (Invitrogen, M7512; 500 nM for 30 minutes at 37°C) and TMRM (Invitrogen, T668; 100 nM for 30 minutes at 37°C).

    Article Title: α-Synuclein aggregates induce mitochondrial damage and trigger innate immunity to drive neuron-microglia communication.
    Article Snippet: .. For inflammatory modulations, following reagents were used with associated treatment concentration and durations: STING activator – diABZI (SelleckChem – compound 3, S8796; 2.5 μM for 2h towards the end of experiment), STING inhibitor – H-151 (Invivogen InvitroFitTM, inhh151; 0.5 μg/mL for 16h for TNT assessment experiments, and 24h for α-Syn transfer experiments), NF-κB inhibitor – JSH-23 (Sigma, J4455; 10 μM for 16h for TNT assessment AR TI CL E IN P RE SS experiments, and 24h for α-Syn transfer experiments), human cGAS inhibitor – G140 (Invivogen InvitroFitTM, inh-g140; 10 μM for 16h), Bcl-2 inhibitor – ABT-737 (Sigma, 197333; 10 μM for 6h, 12h, or 24h) co-treated with pan-caspase inhibitor – Q-VD-OPh (Non-O-methylated, Sigma, 551476, 10 μM), BAX inhibitor – BAI1 (MedChemExpress, HY-103269, 1 μM for 1h followed by a wash and subsequently 100 nM for 16h), human IL-1α (Sigma, I2778; 3 ng/mL for 24h), human IL-1β (Sigma, H6291; 20 ng/mL for 24h), human TNF-α (Merck Millipore, 654205; 50 ng/mL for 24h), TLR4 inhibitor – TAK-242 (Tocris, 6587; 10 μM for 16h), TLR2 inhibitor – TL2-C29 (Invivogen InvitroFitTM, inh-C29; 100 μM for 16h), TLR9 inhibitor – TLR9-IN-1 (MedChemExpress, HY-148045, 10 μM for 16h), RIG1 inhibitor – RIG012 (MedChemExpress, HY-147124, 0.1 μM for 16h), lysosomotropic agent LLOMe (Sigma, L7393; 1 mM for 1h towards the end of experiment), mitochondrial electron transport chain uncoupler CCCP (Sigma, C2759; 20 μM for 2h). .. NPCs at 80-100% confluency were cultured on POLAM-coated (poly-L-ornithine Sigma-aldrich, P4957; laminin, Sigma-Aldrich, L2020) wells in DAn induction medium [DMEM/F12 (Life, 21331-20), 1% N2 (Life, 17502048), 1% Penicillin/Streptomycin (ScienCell, 0503)] supplemented with 200 ng/ml Sonic Hedgehog (PeproTech, 100-45) and 100 ng/ml FGF8 (PeproTech, 100-25) for 6 days.

    Methylation:

    Article Title: α-Synuclein aggregates induce mitochondrial damage and trigger innate immunity to drive neuron–microglia communication
    Article Snippet: .. For inflammatory modulations, following reagents were used with associated treatment concentration and durations: STING activator – diABZI (SelleckChem – compound 3, S8796; 2.5 μM for 2h towards the end of experiment), STING inhibitor – H-151 (Invivogen InvitroFit TM , inh-h151; 0.5 μg/mL for 16h for TNT assessment experiments, and 24h for α-Syn transfer experiments), NF-κB inhibitor – JSH-23 (Sigma, J4455; 10 μM for 16h for TNT assessment experiments, and 24h for α-Syn transfer experiments), human cGAS inhibitor – G140 (Invivogen InvitroFit TM , inh-g140; 10 μM for 16h), Bcl-2 inhibitor – ABT-737 (Sigma, 197333; 10 μM for 6h, 12h, or 24h) co-treated with pan-caspase inhibitor – Q-VD-OPh (Non-O- methylated, Sigma, 551476, 10 μM), human IL-1α (Sigma, I2778; 3 ng/mL for 24h), human IL-1β (Sigma, H6291; 20 ng/mL for 24h), human TNF-α (Merck Millipore, 654205; 50 ng/mL for 24h), TLR4 inhibitor – TAK-242 (Tocris, 6587; 10 μM for 16h), TLR2 inhibitor – TL2-C29 (Invivogen InvitroFit TM , inh-C29; 100 μM for 16h), lysosomotropic agent LLOMe (Sigma, L7393; 1 mM for 1h towards the end of experiment), mitochondrial electron transport chain uncoupler CCCP (Sigma, C2759; 20 μM for 2h). .. The following dyes were used: MitoTracker Red CMX Ros (Invitrogen, M7512; 500 nM for 30 minutes at 37°C) and TMRM (Invitrogen, T668; 100 nM for 30 minutes at 37°C).



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    STING loss- and gain- of function studies support a growth-restraining role in PEL. (A) BCBL1 and (B) BC3 cells were treated with 5 µM <t>H151</t> for 72 hours and subjected to CellTiter-Glo assay. Western blot of STING overexpression 48 hours after electroporation of 100 ng pcDNA3.1 (EV) or 50-100 ng STING plasmid in (C) BCBL1 and (D) BC3 cells. CellTiter-Glo assay in (E) BCBL1 and (F) BC3 cells at 72 hours after EV or STING plasmid electroporation. Data is represented as relative luminescence units. Data (A-B, E-F) are presented as mean ± SD. * indicates p<0.05; ** indicates p<0.01; *** indicates p<0.001 by Student’s t-test.
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    experiment invivogen tlrl bx7 h151 sting inhibitor  (InvivoGen)
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    InvivoGen experiment invivogen tlrl bx7 h151 sting inhibitor
    STING loss- and gain- of function studies support a growth-restraining role in PEL. (A) BCBL1 and (B) BC3 cells were treated with 5 µM <t>H151</t> for 72 hours and subjected to CellTiter-Glo assay. Western blot of STING overexpression 48 hours after electroporation of 100 ng pcDNA3.1 (EV) or 50-100 ng STING plasmid in (C) BCBL1 and (D) BC3 cells. CellTiter-Glo assay in (E) BCBL1 and (F) BC3 cells at 72 hours after EV or STING plasmid electroporation. Data is represented as relative luminescence units. Data (A-B, E-F) are presented as mean ± SD. * indicates p<0.05; ** indicates p<0.01; *** indicates p<0.001 by Student’s t-test.
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    Image Search Results


    STING loss- and gain- of function studies support a growth-restraining role in PEL. (A) BCBL1 and (B) BC3 cells were treated with 5 µM H151 for 72 hours and subjected to CellTiter-Glo assay. Western blot of STING overexpression 48 hours after electroporation of 100 ng pcDNA3.1 (EV) or 50-100 ng STING plasmid in (C) BCBL1 and (D) BC3 cells. CellTiter-Glo assay in (E) BCBL1 and (F) BC3 cells at 72 hours after EV or STING plasmid electroporation. Data is represented as relative luminescence units. Data (A-B, E-F) are presented as mean ± SD. * indicates p<0.05; ** indicates p<0.01; *** indicates p<0.001 by Student’s t-test.

    Journal: Frontiers in Immunology

    Article Title: STING inhibits viral lytic reactivation and cell growth in primary effusion lymphoma

    doi: 10.3389/fimmu.2026.1823240

    Figure Lengend Snippet: STING loss- and gain- of function studies support a growth-restraining role in PEL. (A) BCBL1 and (B) BC3 cells were treated with 5 µM H151 for 72 hours and subjected to CellTiter-Glo assay. Western blot of STING overexpression 48 hours after electroporation of 100 ng pcDNA3.1 (EV) or 50-100 ng STING plasmid in (C) BCBL1 and (D) BC3 cells. CellTiter-Glo assay in (E) BCBL1 and (F) BC3 cells at 72 hours after EV or STING plasmid electroporation. Data is represented as relative luminescence units. Data (A-B, E-F) are presented as mean ± SD. * indicates p<0.05; ** indicates p<0.01; *** indicates p<0.001 by Student’s t-test.

    Article Snippet: BCBL1 and BC3 cells were treated with 5 μM STING inhibitor H151 (MedChemExpress cat# Hy-112693) ( ) prepared in DMSO for 72 hours prior to CellTiter-Glo assay.

    Techniques: Glo Assay, Western Blot, Over Expression, Electroporation, Plasmid Preparation